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Article

Role of LIM kinases in normal and psoriatic human epidermis.

Molecular biology of the cell - 1 Apr 2006

Honma Masaru, Benitah Salvador Aznar, Watt Fiona M

Abstract excerpt

We present evidence that LIM kinases can control cell adhesion and compaction in human epidermis. LIMK2 is expressed in the epidermal basal layer and signals downstream of the GTPase Rac1 to promote extracellular matrix adhesion and inhibit terminal differentiation. Conversely, LIMK1 is expressed in the upper granular layers and phosphorylates and inhibits cofilin. Expression of LIMK1 is lost in psoriatic lesions...

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Share to Cell Adhesion
Share to Epidermal Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

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Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 16467374
DOI: 10.1091/mbc.e05-12-1173
PMCID: PMC1415329

Genes

LIMK1
LIMK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of LIM kinases in normal and psoriatic human epidermis.PMID 16467374Read ↗

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The Slingshot Family of Phosphatases Mediates Rac1 Regulation of Cofilin Phosphorylation, Laminin-332 Organization, and Motility Behavior of KeratinocytesSemantic proximity Read ↗

LIM Kinase 2 Is Widely Expressed in All TissuesSemantic proximity Read ↗

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