Article
Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.
Malaria journal - 7 Feb 2006
Daher Wassim, Biot Christophe, Fandeur Thierry, Jouin Helene, Pelinski Lydie, Viscogliosi Eric, Fraisse Laurent, Pradines Bruno, Brocard Jacques, Khalife Jamal, Dive Daniel
Abstract excerpt
BACKGROUND: Ferroquine (FQ), or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine (CQ) resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested in...
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