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Article

Deregulated expression of PAX5 in medulloblastoma.

6 Jun 1995

Abstract excerpt

Medulloblatoma is a pediatric brain tumor originating in the human cerebellum. A collection of 23 medulloblastomas was analyzed for expression of the developmental control genes of the PAX and EN gene families by RNase protection and in situ hybridization. Of all nine PAX genes investigated, only PAX5 and PAX6 were consistently expressed in most medulloblastomas (70 and 78% of all cases, respectively), as were...

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PMID: 7777574
DOI: 10.1073/pnas.92.12.5709

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