Article
SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Shiu Patrick K T, Zickler Denise, Raju Namboori B, Ruprich-Robert Gwenael, Metzenberg Robert L
Abstract excerpt
A gene unpaired during the meiotic homolog pairing stage in Neurospora generates a sequence-specific signal that silences the expression of all copies of that gene. This process is called Meiotic Silencing by Unpaired DNA (MSUD). Previously, we have shown that SAD-1, an RNA-directed RNA polymerase (RdRP), is required for MSUD. We isolated a second gene involved in this process, sad-2. Mutated Sad-2 (RIP) alleles,...
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