Article
Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.
Applied and environmental microbiology - 1 Feb 2006
Wescombe Philip A, Upton Mathew, Dierksen Karen P, Ragland Nancy L, Sivabalan Senthuran, Wirawan Ruth E, Inglis Megan A, Moore Chris J, Walker Glenn V, Chilcott Chris N, Jenkinson Howard F, Tagg John R
Abstract excerpt
Salivaricin A (SalA), the first Streptococcus salivarius lantibiotic to be characterized, appears to be inhibitory to most Streptococcus pyogenes strains. A variant of the SalA structural gene (salA1) is present in more than 90% of S. pyogenes strains, but only strains of M serotype 4 and T pattern 4 produce the biologically active peptide. The present study identifies four additional variants (salA2 to salA5) of...
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