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Article

Rapid screening method for detecting highly pathogenic Streptococcus intermedius strains carrying a mutation in the lacR gene.

FEMS microbiology letters - 1 Feb 2018

Tomoyasu Toshifumi, Matoba Masaki, Takao Ayuko, Tabata Atsushi, Whiley Robert A, Maeda Nobuko, Nagamune Hideaki

Abstract excerpt

Streptococcus intermedius is a member of the normal human commensal flora and secretes a human-specific cytolysin intermedilysin (ILY) as a major virulence factor. Expression of ily is repressed by LacR and loss-of-function mutations of LacR are observed in many ILY high-producing strains isolated from deep-seated abscesses, suggesting that high ILY production is necessary for increased virulence. However,...

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PMID: 29228148
DOI: 10.1093/femsle/fnx258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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