Article
Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype.
Virology - 10 May 2006
Pal Ranajit, Kalyanaraman V S, Nair B C, Whitney Stephen, Keen Timothy, Hocker Lindsey, Hudacik Lauren, Rose Nicolas, Mboudjeka Innocent, Shen Siyuan, Wu-Chou Te-Hui, Montefiori David, Mascola John, Markham Philip, Lu Shan
Abstract excerpt
The immunogenicity of a poylvalent HIV-1 vaccine comprised of Env antigens from primary R5 isolates was evaluated in rhesus macaques. DNA vaccines encoding four Env antigens from multiple HIV-1 subtypes and HIV-1 Gag antigen from a single subtype elicited a persistent level of binding antibodies to gp120 from multiple HIV-1 isolates that were markedly enhanced following boosting with homologous gp120 proteins in...
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