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An In Vivo Analysis of Hematopoietic Stem Cell Potential

3 Feb 2006

Abstract excerpt

Recent studies evaluating hematopoietic stem cell (HSC) potential raise the possibility that, in addition to embryonic sources, adult valve fibroblasts may be derived from HSCs. To test this hypothesis, we used methods that allow the potential of a single HSC to be evaluated in vivo. This was achieved by isolation and clonal expansion of single lineage-negative (Lin-), c-kit(+), Sca-1(+), CD34- cells from the...

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PMID: 16456103
DOI: 10.1161/01.res.0000207384.81818.d4

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