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Article

Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis.

Pharmacogenomics - 1 Jul 2004

Ranganathan Prabha, Culverhouse Robert, Marsh Sharon, Ahluwalia Ranjeet, Shannon William D, Eisen Seth, McLeod Howard L

Abstract excerpt

Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug in rheumatoid arthritis (RA). Polymorphisms occur in several genes encoding key enzymes in the folic acid pathway, which is influenced by MTX, but have not been evaluated in patients with RA. The effect of race on allele f...

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PMID: 15212592
DOI: 10.1517/14622416.5.5.559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15212592-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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