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Article

Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.

Annals of neurology - 1 Feb 2006

Vandiedonck Claire, Capdevielle Claire, Giraud Matthieu, Krumeich Sophie, Jais Jean-Philippe, Eymard Bruno, Tranchant Christine, Gajdos Philippe, Garchon Henri-Jean

Abstract excerpt

OBJECTIVE: Our objective was to investigate a role of the intracellular tyrosine phosphatase PTPN22*R620W variant in autoimmune myasthenia gravis (MG), considering disease heterogeneity. METHODS: We used a case-control design, comparing 470 patients and 296 controls, all French whites. Patients were categorized depending on the presence of a thymoma and serum anti-titin antibodies. RESULTS: The 620W risk allele...

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Source

Identifiers

PMID: 16437561
DOI: 10.1002/ana.20751

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.PMID 16437561Read ↗

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Recent advances in genetic predisposition of myasthenia gravis.Semantic proximity Read ↗

The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.Semantic proximity Read ↗

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