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Article

Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.

Antimicrobial agents and chemotherapy - 1 Feb 2006

Kosowska-Shick Klaudia, Clark Catherine, Credito Kim, McGhee Pamela, Dewasse Bonifacio, Bogdanovich Tatiana, Appelbaum Peter C

Abstract excerpt

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance...

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Identifiers

PMID: 16436741
DOI: 10.1128/AAC.50.2.765-769.2006
PMCID: PMC1366917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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