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Article

Kinesin-related proteins required for structural integrity of the mitotic spindle.

Cell - 7 Aug 1992

Saunders W S, Hoyt M A

Abstract excerpt

For S. cerevisiae cells, the assembly of a bipolar mitotic spindle requires the action of either Cin8p or Kip1p, gene products related to the mechanochemical enzyme kinesin. In this paper we demonstrate that the activity of either one of these proteins is also required following spindle assembly. When their function was eliminated, preanaphase bipolar spindles rapidly collapsed, with previously separated poles...

Topics

Anaphase
Fungal Proteins
Genes, Fungal
Kinesins
Microscopy, Electron
Microscopy, Fluorescence
Microtubule-Associated Proteins
Molecular Motor Proteins
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spindle Apparatus

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Identifiers

PMID: 1643659
DOI: 10.1016/0092-8674(92)90169-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1643659-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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