Article
Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea.
Current biology : CB - 24 Jan 2006
Wang Shenqiu, Jayaram Satish Arcot, Hemphälä Johanna, Senti Kirsten-André, Tsarouhas Vasilios, Jin Haining, Samakovlis Christos
Abstract excerpt
The function of tubular epithelial organs like the kidney and lung is critically dependent on the length and diameter of their constituting branches. Genetic analysis of tube size control during Drosophila tracheal development has revealed that epithelial septate junction (SJ) components and the dynamic chitinous luminal matrix coordinate tube growth. However, the underlying molecular mechanisms controlling tube...
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