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A calcium‐dependent protein kinase regulates <i>Plasmodium</i> ookinete access to the midgut epithelial cell

13 Dec 2005

Abstract excerpt

Plasmodium parasites are fertilized in the mosquito midgut and develop into motile zygotes, called ookinetes, which invade the midgut epithelium. Here we show that a calcium-dependent protein kinase, CDPK3, of the rodent malarial parasite (Plasmodium berghei) is produced in the ookinete stage and has a critical role in parasite transmission to the mosquito vector. Targeted disruption of the CDPK3 gene decreased...

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PMID: 16430692
DOI: 10.1111/j.1365-2958.2005.05014.x

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