Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.

Nature cell biology - 1 Feb 2006

Muthumani Karuppiah, Choo Andrew Y, Zong Wei-Xing, Madesh Muniswamy, Hwang Daniel S, Premkumar Arumugam, Thieu Khanh P, Emmanuel Joann, Kumar Sanjeev, Thompson Craig B, Weiner David B

Abstract excerpt

The Vpr protein of HIV-1 functions as a vital accessory gene by regulating various cellular functions, including cell differentiation, apoptosis, nuclear factor of kappaB (NF-kappaB) suppression and cell-cycle arrest of the host cell. Several reports have indicated that Vpr complexes with the glucocorticoid receptor (GR), but it remains unclear whether the GR pathway is required for Vpr to function. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Products, vpr
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mifepristone

Share to NF-KappaB Inhibitor alpha

Share to Poly (ADP-Ribose) Polymerase-1

Share to Transcription Factor RelA

Share to U937 Cells

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 16429131
DOI: 10.1038/ncb1352
PMCID: PMC3142937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.PMID 16429131Read ↗

The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product.Semantic proximity Read ↗

HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitroSemantic proximity Read ↗

The Role of Vpr in HIV-1 PathogenesisSemantic proximity Read ↗

HIV-1 Vpr transactivates LTR-directed expression through sequences present within -278 to -176 and increases virus replication in vitro.Semantic proximity Read ↗

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repairSemantic proximity Read ↗

Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-Responsive Promoters by Binding Directly to p300/CBP CoactivatorsSemantic proximity Read ↗

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read ↗

HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventionSemantic proximity Read ↗

HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1Semantic proximity Read ↗

HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr: functions and molecular interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.