Article
Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2003
Combarros Onofre, Rodero Lucía, Infante Jon, Palacio Enrique, Llorca Javier, Fernández-Viadero Carlos, Peña Nicolás, Berciano José
Abstract excerpt
A vigorous controversy exists over whether tau tangles or amyloid-beta plaques are the primary cause of neurodegeneration in Alzheimer's disease (AD), and it is not well established whether genetic variation in tau is associated with AD. A recently identified novel protein, named Saitohin (STH), shares tissue expression pattern with tau, and preliminary evidence in a North American population indicates that a...
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