Article
Conservation and diversity of HMW1 and HMW2 adhesin binding domains among invasive nontypeable Haemophilus influenzae isolates.
Infection and immunity - 1 Feb 2006
Giufrè Maria, Muscillo Michele, Spigaglia Patrizia, Cardines Rita, Mastrantonio Paola, Cerquetti Marina
Abstract excerpt
The pathogenesis of nontypeable Haemophilus influenzae (NTHi) begins with adhesion to the rhinopharyngeal mucosa. In almost 80% of NTHi clinical isolates, the HMW proteins are the major adhesins. The prototype HMW1 and HMW2 proteins, identified in NTHi strain 12, exhibit different binding specificities. The two binding domains have been localized in regions of maximal sequence dissimilarity (40% identity, 58%...
Topics
- Adhesins, Bacterial
- Amino Acid Sequence
- Bacterial Adhesion
- Conserved Sequence
- Genetic Variation
- Haemophilus influenzae
- Humans
- Molecular Sequence Data
- Phylogeny
- Sequence Analysis, DNA