Article
Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein.
RNA (New York, N.Y.) - 1 Feb 2006
Chmiel Nikolas H, Rio Donald C, Doudna Jennifer A
Abstract excerpt
Drosophila P-element somatic inhibitor protein (PSI) regulates splicing of the P-element transposase pre-mRNA by binding a pseudo-splice site upstream of the authentic splice site using four tandem KH-type RNA binding motifs. While the binding domains and specificity of PSI have been established, little is known about the contributions of each PSI KH domain to overall protein stability and RNA binding affinity....
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