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Article

Evolution of a carbohydrate binding module into a protein-specific binder.

Biomolecular engineering - 1 Jun 2006

Gunnarsson Lavinia Cicortas, Dexlin Linda, Karlsson Eva Nordberg, Holst Olle, Ohlin Mats

Abstract excerpt

A carbohydrate binding module, CBM4-2, derived from the xylanase (Xyn 10A) of Rhodothermus marinus has been used as a scaffold for molecular diversification. Its binding specificity has been evolved to recognise a quite different target, a human monoclonal IgG4. In order to understand the basis for this drastic change in specificity we have further investigated the target recognition of the IgG4-specific CBMs....

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Identifiers

PMID: 16427804
DOI: 10.1016/j.bioeng.2005.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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