Alloreactive CD4⁺ and CD8⁺ T cells express the immunotolerant HLA‐G molecule in mixed lymphocyte reactions: <i>in vivo</i> implications in transplanted patients

Abstract excerpt

HLA-G displays immunotolerogenic properties towards the main effector cells involved in graft rejection through inhibition of NK- and CTL-mediated cytolysis and CD4+ T cell alloproliferation. HLA-G expression is restricted in healthy tissues to trophoblast and thymus but is extended to various tissues under pathological conditions. HLA-G was detected in allograft biopsies and sera from transplanted patients who...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endometriosis Research and Treatment
• Share to Reproductive Biology and Fertility
• Share to Reproductive System and Pregnancy