Article
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine.
Transplantation - 15 Jan 2006
Nobori Shuji, Samelson-Jones Emma, Shimizu Akira, Hisashi Yosuke, Yamamoto Shin, Kamano Chisako, Teranishi Katsuhito, Vagefi Parsia A, Nuhn Mathew, Okumi Masayoshi, Wong Banny, Houser Stuart, Sachs David H, Yamada Kazuhiko
Abstract excerpt
BACKGROUND: We have previously reported the ability of both thymokidney and vascularized thymic lobe (VTL) allografts to induce transplantation tolerance to renal allografts across a full major histocompatibility complex (MHC) mismatch in thymectomized miniature swine. However, whether vascularized thymus is capable of inducing tolerance to less tolerogeneic organs when it is transplanted simultaneously is not...
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