Article
ACE gene polymorphism in children with nephrotic syndrome in the Indonesian population.
The Kobe journal of medical sciences - 1 Jan 2005
Sasongko Teguh Haryo, Sadewa Ahmad Hamim, Kusuma Pungky Ardani, Damanik Martua Parlindungan, Lee Myeong Jin, Ayaki Hitoshi, Nozu Kandai, Goto Akinobu, Matsuo Masafumi, Nishio Hisahide
Abstract excerpt
BACKGROUND: The angiotensin converting enzyme (ACE) gene carries insertion (I) and deletion (D) polymorphism within its intron 16. The presence of D-allele in the ACE gene has been reported as a probable genetic risk factor for idiopathic nephrotic syndrome (INS), especially the subtype of focal segmental glomerulosclerosis (FSGS). The D-allele may be related to poor responsiveness to steroid therapy. To clarify...
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