Article
Significance of circulating T-cell clones in Sezary syndrome.
Blood - 15 May 2006
Ortonne Nicolas, Huet Delphine, Gaudez Caroline, Marie-Cardine Anne, Schiavon Valérie, Bagot Martine, Musette Philippe, Bensussan Armand
Abstract excerpt
Identification of malignant Sézary cells by T-cell receptor (TCR) clonality studies is routinely used for the diagnosis of Sézary syndrome, but T-cell clones expressed in a single patient have never been accurately characterized. We previously reported that CD158k expression delineates Sézary syndrome malignant cells, and, more recently, we identified vimentin at the surface membranes of Sézary cells and normal...
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