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Article

Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients.

15 Nov 1993

Abstract excerpt

Autosomal dominant of Charcot-Marie-Tooth disease (CMT), whose gene is type 1B (CMT1B), has slow nerve conduction with demyelinated Schwann cells. In this study the abundant peripheral myelin protein zero (MPZ) gene, MPZ, was mapped 130 kb centromeric to the Fc receptor immunoglobulin gene cluster in band 1q22, and a major MPZ point mutation was found to cosegregate with CMT1B in one large CMT1B family. The MPZ...

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Identifiers

PMID: 7504284
DOI: 10.1073/pnas.90.22.10856

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Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients.PMID 7504284Read ↗

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