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Article

MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists.

Clinical pharmacology and therapeutics - 1 Jan 2006

Meisel Peter, Giebel Jürgen, Kunert-Keil Christiane, Dazert Peter, Kroemer Heyo K, Kocher Thomas

Abstract excerpt

BACKGROUND: Gingival overgrowth is a common side effect of calcium antagonists. Although the pathogenesis is unknown, several lines of evidence point to a modulation of inflammatory processes. Because the calcium antagonists, albeit to a variable degree, act as inhibitors of P-glycoprotein (P-gp), the gene product of multidrug resistance 1 (MDR1), and inflammation may modify P-gp expression, we analyzed the MDR1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16413242
DOI: 10.1016/j.clpt.2005.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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