Article
Bovine papillomavirus type 1 oncoprotein E5 stimulates the utilization of superoxide radicals in the mouse fibroblast cell line C127.
Chemico-biological interactions - 25 Feb 2006
Kilk Ann, Rausalu Kai, Ustav Mart
Abstract excerpt
The major transforming protein of bovine papillomavirus type 1 (BPV-1) is a small hydrophobic polypeptide, the E5 gene product, localized in the cellular membranes and modulating various pathways in the cell. Many studies have shown that reactive oxygen species (ROS) are essential in several biological processes, including cell transformation by oncogenes, but unregulated ROS are highly toxic to cells. We studied...
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