Article
The multiple sclerosis trait and the development of multiple sclerosis: genetic vulnerability and environmental effect.
Clinical neurology and neurosurgery - 1 Mar 2006
Poser Charles M
Abstract excerpt
The remarkably low rate of concordance of multiple sclerosis (MS) in monozygotic twins has never been fully explained but it implies the possibility of a systemic condition called the multiple sclerosis trait (MST), which is quite different from asymptomatic MS. It results from the action of an antigenic challenge on the immune system of a genetically vulnerable person that does not cause damage to the nervous...
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