Article
Pre-symptomatic diagnosis in fatal familial insomnia: serial neurophysiological and 18FDG-PET studies.
Brain : a journal of neurology - 1 Mar 2006
Cortelli Pietro, Perani Daniela, Montagna Pasquale, Gallassi Roberto, Tinuper Paolo, Provini Federica, Federica Provini, Avoni Patrizia, Ferrillo Franco, Anchisi Davide, Moresco Rosa Maria, Fazio Ferruccio, Parchi Piero, Baruzzi Agostino, Lugaresi Elio, Gambetti Pierluigi
Abstract excerpt
Knowing how and when the degenerative process starts is important in neurodegenerative diseases. We have addressed this issue in fatal familial insomnia (FFI) measuring the cerebral metabolic rate of glucose (CMRglc) with 2-[18F]fluoro-2-deoxy-D-glucose PET in parallel with detailed clinical, neuropsychological examinations and polysomnography with EEG spectral analyses. Nine asymptomatic carriers of the D178N...
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