Article
Clinical and genetic studies of fatal familial insomnia.
Neurology - 1 Jun 1995
Reder A T, Mednick A S, Brown P, Spire J P, Van Cauter E, Wollmann R L, Cervenàkovà L, Goldfarb L G, Garay A, Ovsiew F
Abstract excerpt
We report a 42-year-old man who, for 8 months, had intermittent motor abnormalities and mild difficulty falling asleep. A diagnosis of fatal familial insomnia (FFI) became evident over the next 6 months when he developed progressive insomnia, myoclonus, sympathetic hyperactivity, and dementia. Th...
Topics
- Adult
- Cerebral Cortex
- Fatal Outcome
- Hormones
- Humans
- Male
- Mutation
- Prions
- Sleep Initiation and Maintenance Disorders