Article
Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function.
Cancer research - 1 May 2002
Gelmann Edward P, Steadman David J, Ma Jing, Ahronovitz Natalie, Voeller H James, Swope Sheridan, Abbaszadegan Mohammed, Brown Kevin M, Strand Kate, Hayes Richard B, Stampfer Meir J
Abstract excerpt
NKX3.1, a member of the NK class of homeodomain proteins, is expressed primarily in the adult prostate and has growth suppression and differentiating effects in prostate epithelial cells. A C-->T polymorphism at nucleotide 154 (NKX3.1 C154T) is present in approximately 11% of healthy men with equal distribution among whites and blacks. In a cohort of 1253 prostate cancer patients and age-matched controls, the...
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