Article
Iron binding saturation and genotypic testing for hereditary hemochromatosis in patients with liver disease.
American journal of clinical pathology - 1 Feb 2006
Nichols Larry, Dickson Gretchen, Phan Phu G, Kant Jeffrey A
Abstract excerpt
We compared the results of HFE genotype with tests for iron binding saturation (IBS) in 190 consecutive patients with liver disease using 2 IBS cutoff levels: 45% and 60%. Saturation was more than 45% in 117 patients (61.6%) and more than 60% in 89 (46.8%). The number of patients (10) with the highest-risk HFE genotype (C282Y homozygote) was higher than expected. Elevated IBS cannot be used to predict genotype....
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