Article
Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort.
European journal of human genetics : EJHG - 1 Mar 2006
Wilson Scott G, Adam Gail, Langdown Maria, Reneland Rikard, Braun Andreas, Andrew Toby, Surdulescu Gabriela L, Norberg Maria, Dudbridge Frank, Reed Peter W, Sambrook Philip N, Kleyn Patrick W, Spector Tim D
Abstract excerpt
Obesity is a multifactorial disorder with a complex phenotype. It is a significant risk factor for diabetes and hypertension. We assessed obesity-related traits in a large cohort of twins and performed a genome-wide linkage scan and positional candidate analysis to identify genes that play a role in regulating fat mass and distribution in women. Dizygous female twin pairs from 1,094 pedigrees were studied (mean...
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