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The maternal age effect: a hypothesis based on oxidative phosphorylation

1 Nov 2005

Abstract excerpt

The 'maternal age effect' in human reproduction, characterized by a negative relationship between maternal age and reproductive efficiency, remains a poorly understood phenomenon. Current data suggest that oocyte physiology determines this relationship. In this review, we present a hypothesis of a mitochondrial role in the physiology of ageing in human oocytes. We suggest that the efficiency of oxidative...

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PMID: 16388700
DOI: 10.1017/s0967199405003382

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