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Article

Cellular and molecular aspects of ovarian follicle ageing

31 Jan 2008

Abstract excerpt

It is well established that age-related decline of the biological capacity of a woman to reproduce is primarily related to the poor developmental potential of her gametes. This renders female ageing the most significant determinant of success in IVF. Starting with a reference picture of the main molecular and cellular failures of aged oocytes, granulosa cells and follicular microenvironment, this review focuses...

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PMID: 18239135
DOI: 10.1093/humupd/dmm048

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