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Article

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Wang Runsheng, Tang Phuong, Wang Pei, Boissy Raymond E, Zheng Hui

Abstract excerpt

Presenilins (PS) are required for gamma-secretase cleavage of multiple type I membrane proteins including the amyloid precursor protein and Notch and also have been implicated in regulating intracellular protein trafficking and turnover. Using genetic and pharmacological approaches, we reveal here a unique function of PS in the pigmentation of retinal pigment epithelium and epidermal melanocytes. PS deficiency...

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Identifiers

PMID: 16384915
DOI: 10.1073/pnas.0509822102
PMCID: PMC1326180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.PMID 16384915Read ↗

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