Article
Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.
Nature genetics - 1 Feb 2006
Gilbert Sandra L, Zhang Li, Forster Michele L, Anderson Jeffrey R, Iwase Tamaki, Soliven Betty, Donahue Leah Rae, Sweet Hope O, Bronson Roderick T, Davisson Muriel T, Wollmann Robert L, Lahn Bruce T
Abstract excerpt
Hypertonia, which results from motor pathway defects in the central nervous system (CNS), is observed in numerous neurological conditions, including cerebral palsy, stroke, spinal cord injury, stiff-person syndrome, spastic paraplegia, dystonia and Parkinson disease. Mice with mutation in the hypertonic (hyrt) gene exhibit severe hypertonia as their primary symptom. Here we show that hyrt mutant mice have much...
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