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Article

DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition.

PloS one - 1 Jan 2012

Bode Nicole, Massey Cory, Gonzalez-Alegre Pedro

Abstract excerpt

DYT1 is caused by a partly penetrant dominant mutation in TOR1A that leads to a glutamic acid deletion (ΔE) in torsinA. Identifying environmental factors that modulate disease pathogenesis and penetrance could help design therapeutic strategies for dystonia. Several cell-based studies suggest that expression of torsinA(ΔE) increases the susceptibility of neuronal cells to challenges to their oxidative/energy...

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Identifiers

PMID: 22880064
DOI: 10.1371/journal.pone.0042644
PMCID: PMC3411799

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