Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon Regulatory Factor 3 Is Necessary for Induction of Antiviral Genes during Human Cytomegalovirus Infection

26 Dec 2005

Abstract excerpt

Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon-stimulated genes (ISGs). The role of IRF3 in the activation of ISGs by human cytomegalovirus (HCMV) is controversial despite the fact that HCMV has consistently been shown to induce ISGs during infection of fibroblasts. To address the function of IRF3 in HCMV-mediated ISG induction, we monitored ISG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to interferon and immune responses
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16379004
DOI: 10.1128/jvi.80.2.1032-1037.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon Regulatory Factor 3 Is Necessary for Induction of Antiviral Genes during Human Cytomegalovirus InfectionPMID 16379004Read ↗

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 ExpressionSemantic proximity Read ↗

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding ComplexSemantic proximity Read ↗

Human Cytomegalovirus Elicits a Coordinated Cellular Antiviral Response via Envelope Glycoprotein BSemantic proximity Read ↗

IFN Regulatory Factor 3 in Health and DiseaseSemantic proximity Read ↗

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cellsSemantic proximity Read ↗

Interferon-Independent Innate Responses to CytomegalovirusSemantic proximity Read ↗

Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.Semantic proximity Read ↗

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1Semantic proximity Read ↗

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferonsSemantic proximity Read ↗

Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human CytomegalovirusSemantic proximity Read ↗

Early Innate Immune Responses to Sin Nombre Hantavirus Occur Independently of IFN Regulatory Factor 3, Characterized Pattern Recognition Receptors, and Viral EntrySemantic proximity Read ↗

RNA Interference-Mediated Targeting of Human Cytomegalovirus Immediate-Early or Early Gene Products Inhibits Viral Replication with Differential Effects on Cellular FunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.