Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation inactivating the methyltransferase gene in avirulent Madrid E strain of Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir.

Vaccine - 20 Mar 2006

Zhang Jian-Zhi, Hao Jun-Fang, Walker David H, Yu Xue-Jie

Abstract excerpt

Rickettsia prowazekii Madrid E (E) strain is an effective vaccine, but can revert to virulent status when passaged in animals. The aim of this study is to identify the reverse mutation that may determine the virulence of R. prowazekii by comparing the genetic structures of E strain and its virulent revertant Evir strain. We determined that the gene (Rp028/Rp027) encoding the methyltransferase was mutated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Open Reading Frames

Share to S-Adenosylmethionine

Share to Transcription, Genetic

Share to Virulence

Source

Identifiers

PMID: 16364512
DOI: 10.1016/j.vaccine.2005.11.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation inactivating the methyltransferase gene in avirulent Madrid E strain of Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir.PMID 16364512Read ↗

Inactivation of SAM-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain.Semantic proximity Read ↗

Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities.Semantic proximity Read ↗

Possible biased virulence attenuation in the Senegal strain of <i>Ehrlichia ruminantium</i> by <i>ntrX</i> gene conversion from an inverted segmental duplicationSemantic proximity Read ↗

Avirulence of a spontaneous Francisella tularensis subsp. mediasiatica prmA mutant.Semantic proximity Read ↗

Wild and attenuated vaccine RS-12 strains of mumps virus exhibit differences in amino acid sequences of their proteins.Semantic proximity Read ↗

Attenuated Mutants of Ehrlichia chaffeensis Induce Protection against Wild-Type Infection Challenge in the Reservoir Host and in an Incidental HostSemantic proximity Read ↗

Nucleotide sequences of IRES domains IV and V of natural ECHO virus type 11 isolates with different replicative capacity phenotypes.Semantic proximity Read ↗

Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine HostSemantic proximity Read ↗

Examination of rickettsial host range for shuttle vectors based on <i>dnaA</i> and <i>parA</i> genes from the pRM plasmid of <i>Rickettsia monacensis</i>Semantic proximity Read ↗

Transformation of Rickettsia prowazekii to rifampin resistance.Semantic proximity Read ↗

Regulator of Actin-Based Motility (RoaM) Downregulates Actin Tail Formation by Rickettsia rickettsii and Is Negatively Selected in Mammalian Cell CultureSemantic proximity Read ↗

Use of reassortant viruses to map attenuating and temperature-sensitive mutations of the Rift Valley fever virus MP-12 vaccine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.