Article
Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.
Gynecologic oncology - 1 Jun 2006
Joseph Thomas, Chacko Priya, Wesley Remani, Jayaprakash P G, James Francis V, Pillai M Radhakrishna
Abstract excerpt
OBJECTIVES: Host genetic factors may play a role in human papillomavirus (HPV)-associated tumorigenesis, although the issue continues to be a focus of much debate. Biotransformation is critical in carcinogenic activity of numerous environmental carcinogens. It is therefore possible that polymorphisms of genes producing functional changes in xenobiotic metabolizing enzymes may be susceptible factors in cervical...
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