Article
American founder mutation for Lynch syndrome. Prevalence estimates and implications.
Cancer - 15 Jan 2006
Lynch Henry T, de la Chapelle Albert, Hampel Heather, Wagner Anja, Fodde Riccardo, Lynch Jane F, Okimoto Ross, Clark Mary Beth, Coronel Stephanie, Trowonou Abdon, Fu Yun-Xin, Haynatzki Gleb R, Gong Gordon
Abstract excerpt
BACKGROUND: Recently, a new founder mutation, an exon 1-6 deletion in a mismatch repair gene (MMR), MSH2, in nine kindreds with Lynch syndrome was reported. In 3 of the kindreds this mutation was traced by genealogy through 11-12 generations to a common founder, and thus termed the American Found...
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