Article
Pharmacogenetics and cardiac ion channels.
Vascular pharmacology - 1 Feb 2006
Roepke Torsten K, Abbott Geoffrey W
Abstract excerpt
Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na(+) and Ca(2+) ion influx, and K(+) ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has seen a leap in our understanding of the molecular genetic origins of inherited cardiac arrhythmia,...
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