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Article

Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis.

International journal of molecular sciences - 13 Apr 2023

Shrestha Nirajan, Rout-Pitt Nathan, McCarron Alexandra, Jackson Courtney A, Bulmer Andrew C, McAinch Andrew J, Donnelley Martin, Parsons David W, Hryciw Deanne H

Abstract excerpt

Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR), causes essential fatty acid deficiency. The aim of this study was to characterize fatty acid handling in two rodent models of CF; one strain which harbors the loss of phenylalanine at position 508 (Phe508del) in CFTR and the other lacks functional CFTR (510X). Fatty acid concentrations were determined using gas...

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Identifiers

PMID: 37108362
DOI: 10.3390/ijms24087194
PMCID: PMC10138779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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