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p53 Mediates the Accelerated Onset of Senescence of Endothelial Progenitor Cells in Diabetes

10 Dec 2005

Abstract excerpt

Adverse metabolic factors, including oxidized small and dense low density lipoprotein (ox-dmLDL) can contribute to the reduced number and the impaired functions of circulating endothelial progenitors (EPC) in diabetic patients. To elucidate the molecular mechanisms involved, EPC from normal donors were cultured in the presence of ox-dmLDL. Under these experimental conditions EPC undergo to senescent-like growth...

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PMID: 16339764
DOI: 10.1074/jbc.m509293200

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