Gene regulation and deregulation: a beta globin perspective.

doi:10.1054/blre.2000.0128

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Article

Gene regulation and deregulation: a beta globin perspective.

Blood reviews - 1 Jun 2000

Ho P J, Thein S L

Abstract excerpt

The study of the beta globin gene has provided great insights into the mechanisms of gene regulation and expression. In this review, we consider the normal regulation and expression of the beta globin gene and illustrate how the various steps may be affected, providing a basis for understanding the molecular pathophysiology of beta thalassemia. Mutations causing beta thalassemia can be classified as beta0 or B+...

Topics

Gene Expression Regulation
Globins
Humans
Locus Control Region
Mutation
Transcription Factors
beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 11012251
DOI: 10.1054/blre.2000.0128

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