Article
Modulation of neuropeptide Y expression in adult mice does not affect feeding.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005
Ste Marie Linda, Luquet Serge, Cole Toby B, Palmiter Richard D
Abstract excerpt
Despite numerous experiments showing that administration of neuropeptide Y (NPY) to rodents stimulates feeding and obesity, whereas acute interference with NPY signaling disrupts feeding and promotes weight loss, NPY-null mice have essentially normal body weight regulation. These conflicting observations suggest that chronic lack of NPY during development may lead to compensatory changes that normalize regulation...
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