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Article

Does 'soluble' HLA-G really exist? Another twist to the tale

5 Dec 2005

Abstract excerpt

HLA-G is thought to play a key role in implantation by modulating cytokine secretion to control trophoblast invasion and to maintain a local immunosuppressive state. It differs from other class I molecules in that the gene can be alternatively spliced to produce four membrane-bound (G1, G2, G3 and G4) and three soluble isoforms (G5, G6 and G7). The soluble isoforms have recently attracted attention as their...

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Identifiers

PMID: 16330473
DOI: 10.1093/molehr/gah196

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