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Article

Protein design simulations suggest that side-chain conformational entropy is not a strong determinant of amino acid environmental preferences.

Proteins - 15 Mar 2006

Hu Xiaozhen, Kuhlman Brian

Abstract excerpt

Loss of side-chain conformational entropy is an important force opposing protein folding and the relative preferences of the amino acids for being buried or solvent exposed may be partially determined by which amino acids lose more side-chain entropy when placed in the core of a protein. To investigate these preferences, we have incorporated explicit modeling of side-chain entropy into the protein design...

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PMID: 16317667
DOI: 10.1002/prot.20786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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