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Article

Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2.

The Biochemical journal - 15 Mar 2006

Childress Chandra, Lin Qiong, Yang Wannian

Abstract excerpt

SH3PX1 [SNX9 (sorting nexin 9)] is a member of SNX super-family that is recognized by sharing a PX (phox homology) domain. We have previously shown that SH3PX1, phosphorylated by ACK2 (activated Cdc42-associated tyrosine kinase 2), regulates the degradation of EGF (epidermal growth factor) receptor. In mapping the tyrosine phosphorylation region, we found that the C-terminus of SH3PX1 is required for its tyrosine...

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Identifiers

PMID: 16316319
DOI: 10.1042/BJ20050576
PMCID: PMC1383719

Genes

EGF
SNX9

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