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Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning

28 Nov 2005

Abstract excerpt

Nuclear transfer (NT) has potential applications in agriculture and biomedicine, but the technology is hindered by low efficiency. Global gene expression analysis of clones is important for the comprehensive study of nuclear reprogramming. Here, we compared global gene expression profiles of individual bovine NT blastocysts with their somatic donor cells and fertilized control embryos using cDNA microarray...

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PMID: 16314565
DOI: 10.1073/pnas.0508952102

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